Gundersen HJ, Jensen EB (1987) The efficiency of systematic sampling in stereology and its prediction. In addition to behavioral expertise, more desirable applicants will have experience with some of the following techniques: stereotactic surgery, histology, immunohistochemistry, and unbiased stereology. HPLC, stereology, confocal imaging, immunohistochemistry/immunocytochemistry, and other standard molecular biology methods such as Western blotting and RT -ДЇigure 3: Protein analysis, morphometry and stereology of regenerated lung constructs. If 'good' is defined as something having 'accuracy,' where accuracy is defined by limits imposed on variables, then complex questions and answers can be reduced to several variables contained within the same equations.Top and bottom insets show corresponding H&E-stained views of lung sections with superimposed stereology disectors. When setting out to study such changes, we are confronted not only by the task of choosing 'good' questions, but also by the far more challengГ‚В ing one of finding correspondingly 'good' answers. The scope of the discussion has been simplified somewhat by restricting it to a consideration of several possible 'answers' to a single question, namely: What are we measuring when we measure a change? Pharmacologically induced changes in cells represent very complex events. Any information explosion, similar to the one now occurring, is expected to generate a healthy debate regarding the collection and use of such informaГ‚В tion, and the purpose of this review is to look at some of the problemsГ‚В related to interpreting information-that we may be facing in the future. The trend in pharmacological problem solving is clearly moving in the direction of collecting more and more detailed information, which in tum is being called upon to evaluate the effectiveness and safety of drugs. Annual Review of Pharmacology and Toxicology Annual Reviews Complex information-in this form-can be accommodated If 'good' is defined as something having 'accuracy,' where accuracy is defined by limits imposed on variables, then complex questions and answers can be reduced to several variables contained within the same equations. Stereology: Applications to Pharmacology Stereology: Applications to Pharmacology

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